Portal Log inGet Started

Navigate the Ecosystem

v.2026

Ecosystem

The Hybrid Clinic

Telehealth + calibration hubs

Meet the Clinical Director

Dr. Laura Purdy, MD

Vitality Membership

Continuity & ecosystem pricing

Find My Program Member Login / Register

OPTIMIZEMONITORELEVATE

Knowledge graph · Conditions

Canonical Medical Conditions

Every condition oMeds addresses has a canonical entity page mapping its symptoms, biomarkers, medications, and pathways. This is the entry point to the oMeds healthcare knowledge graph.

Medically reviewed

Dr. Laura Purdy · MD, MBA

Clinical Director, oMeds

Last reviewedMay 29, 2026

hormonal

Hormonal conditions

Low Testosterone

Hypogonadism · Andropause

Low testosterone is a clinical state in which a man's circulating testosterone falls below the optimal range and produces symptoms — fatigue, low libido, slow recovery, brain fog, body-composition shift. Diagnosis requires both confirmed biomarkers and symptom correlation.

Perimenopause

Menopausal Transition · Climacteric

Perimenopause is the multi-year hormonal transition before menopause, characterized by fluctuating estradiol and progesterone, irregular cycles, vasomotor symptoms, and metabolic shifts. It typically begins in the 40s and ends 12 months after the final menstrual period.

Menopause

Postmenopause · Surgical Menopause

Menopause is the permanent cessation of menses, confirmed after 12 consecutive months without a period. Estradiol and progesterone are persistently low. Symptoms can extend years into postmenopause and overlap with cardiometabolic and bone-density risk.

Androgenetic Alopecia

Male Pattern Hair Loss · Female Pattern Hair Loss

Androgenetic alopecia is a hereditary, androgen-mediated pattern of progressive hair miniaturization affecting roughly half of men by age 50 and a substantial share of women postmenopause. Early intervention preserves more follicles than late-stage rescue.

Hypothyroidism

Underactive Thyroid

Hypothyroidism is under-production of thyroid hormone, most commonly from autoimmune destruction. It presents with fatigue, cold intolerance, weight gain, and constipation.

Hashimoto's Thyroiditis

Chronic Lymphocytic Thyroiditis · Autoimmune Thyroiditis

Hashimoto's thyroiditis is autoimmune destruction of the thyroid gland and the most common cause of hypothyroidism in iodine-sufficient populations.

Hyperthyroidism

Overactive Thyroid · Thyrotoxicosis

Hyperthyroidism is over-production of thyroid hormone, presenting with weight loss, heat intolerance, palpitations, anxiety, and tremor.

Graves' Disease

Toxic Diffuse Goiter

Graves' disease is an autoimmune cause of hyperthyroidism driven by TSH receptor stimulating antibodies. It commonly presents with thyrotoxicosis, goiter, and orbitopathy.

Polycystic Ovary Syndrome (PCOS)

Polycystic Ovaries · Stein-Leventhal Syndrome

PCOS is a common hormonal condition in women characterized by androgen excess, ovulatory dysfunction, and frequently insulin resistance.

Estrogen Dominance

Functional Estrogen Excess

Estrogen dominance is a functional pattern in which estradiol is high relative to progesterone, contributing to breast tenderness, mood symptoms, heavy menses, and fluid retention.

Low Progesterone

Luteal Insufficiency

Low progesterone in women reflects insufficient luteal-phase production and is commonly seen in perimenopause and luteal-phase defects.

Premenstrual Syndrome (PMS)

Premenstrual Dysphoric Disorder

PMS is a cyclical pattern of physical and mood symptoms in the luteal phase, resolving with menses. PMDD is the severe subtype with marked mood dysregulation.

Cortisol Dysregulation

HPA Axis Dysfunction · Functional Adrenal Dysfunction

Cortisol dysregulation describes a flattened diurnal rhythm or inappropriately high/low cortisol output, contributing to fatigue, sleep disruption, and metabolic shifts.

DHEA Deficiency

Functional Adrenal Androgen Insufficiency

Low DHEA-S can reflect adrenal under-reserve in chronic stress, aging, or pituitary dysfunction. It is reviewed within broader hormone optimization.

Premature Ovarian Insufficiency

POI · Premature Menopause

Premature ovarian insufficiency is loss of ovarian function before age 40, producing menopausal symptoms, fertility loss, and accelerated bone and cardiovascular risk.

Hyperprolactinemia

Elevated Prolactin

Hyperprolactinemia can suppress reproductive hormones and contribute to low libido, infertility, galactorrhea, and amenorrhea. Causes include pituitary adenoma, medications, and hypothyroidism.

Adrenal Insufficiency

Addison's Disease · Hypoadrenalism

Adrenal insufficiency is inadequate cortisol production by the adrenal cortex. Symptoms include fatigue, hypotension, weight loss, and salt craving. Diagnosis requires AM cortisol, ACTH, and stimulation testing.

Cushing Syndrome

Hypercortisolism

Cushing syndrome is chronic cortisol excess from endogenous overproduction or exogenous glucocorticoids. It presents with central adiposity, hypertension, glucose intolerance, and muscle wasting.

Subclinical Hypothyroidism

Mild Thyroid Failure · Compensated Hypothyroidism

Subclinical hypothyroidism is elevated TSH with normal free T4. Treatment candidacy depends on TSH magnitude, antibody status, symptom burden, pregnancy, and cardiovascular risk.

Endometriosis

Endometrial Tissue Disorder

Endometriosis is the growth of endometrial-like tissue outside the uterus, driving cyclical pelvic pain, dysmenorrhea, dyspareunia, and infertility. Diagnosis is clinical and often confirmed by laparoscopy.

Uterine Fibroids

Leiomyomas · Myomas

Uterine fibroids are benign estrogen-responsive smooth-muscle tumors of the uterus. They cause heavy menstrual bleeding, pelvic pressure, and reproductive complications.

Female Pattern Hair Loss

FPHL · Female Androgenetic Alopecia

Female pattern hair loss is progressive central scalp thinning driven by androgen sensitivity and a genetic predisposition. Iron status, thyroid function, and androgen profile shape candidacy.

Hormonal Acne

Androgen-Driven Acne · Adult Acne

Hormonal acne is androgen-driven sebaceous activity producing jawline and chin lesions, often cycle-correlated in women. SHBG, free androgens, and insulin sensitivity shape severity.

Premenstrual Dysphoric Disorder

PMDD · Severe PMS

Premenstrual dysphoric disorder is a severe luteal-phase mood disorder driven by sensitivity to normal progesterone and allopregnanolone fluctuation. It causes significant functional impairment.

metabolic

Metabolic conditions

Metabolic Syndrome

Insulin Resistance Syndrome · Syndrome X

Metabolic syndrome is a cluster of biomarker and anthropometric findings — central adiposity, elevated triglycerides, low HDL, elevated blood pressure, and impaired fasting glucose — that together raise long-term cardiovascular and diabetes risk.

Insulin Resistance

Impaired Insulin Sensitivity · Pre-Diabetic Insulin Resistance

Insulin resistance is a state in which cells respond poorly to insulin, forcing the pancreas to secrete more insulin to maintain euglycemia. It precedes prediabetes and metabolic syndrome by years and is reversible with targeted intervention.

Obesity

Adiposity-Based Chronic Disease · ABCD

Obesity is a chronic, relapsing condition of excess adiposity associated with metabolic, cardiovascular, hormonal, and musculoskeletal sequelae. It is treated as a physiologic disease — not a willpower deficit — and responds to medical, behavioral, and surgical pathways.

Type 2 Diabetes

T2DM · Adult-Onset Diabetes

Type 2 diabetes is chronic hyperglycemia driven by insulin resistance and progressive beta-cell dysfunction. It carries substantial cardiovascular, renal, and neurologic risk.

Prediabetes

Impaired Glucose Tolerance · Impaired Fasting Glucose

Prediabetes is impaired glucose regulation — A1C 5.7–6.4%, fasting glucose 100–125 mg/dL, or impaired glucose tolerance — that precedes type 2 diabetes.

Dyslipidemia

Hyperlipidemia · Mixed Lipid Disorder

Dyslipidemia is abnormal circulating lipids — elevated LDL or non-HDL cholesterol, elevated triglycerides, low HDL, or elevated ApoB — that drive atherosclerotic cardiovascular disease risk.

Familial Hypercholesterolemia

FH · Hereditary High Cholesterol

Familial hypercholesterolemia is an inherited disorder of LDL receptor function producing lifelong elevation of LDL cholesterol and substantially elevated atherosclerotic risk.

Hypertension

High Blood Pressure · HTN

Hypertension is sustained elevation of arterial blood pressure that drives cardiovascular, renal, and cerebrovascular risk. It is largely asymptomatic until end-organ damage.

Non-Alcoholic Fatty Liver Disease (NAFLD)

MAFLD · Hepatic Steatosis

NAFLD is hepatic fat accumulation in the absence of significant alcohol use. It is strongly tied to insulin resistance and metabolic syndrome and can progress to NASH and cirrhosis.

Gout

Monosodium Urate Arthropathy · Hyperuricemia

Gout is recurrent monoarticular arthritis caused by monosodium urate crystal deposition, frequently with hyperuricemia. It is strongly tied to metabolic syndrome.

Metabolic Dysfunction-Associated Steatohepatitis

MASH · NASH

MASH is progressive hepatic inflammation and fibrosis layered on metabolic-associated fatty liver. Drivers include insulin resistance, visceral adiposity, dyslipidemia, and inflammation.

Hypertriglyceridemia

High Triglycerides

Hypertriglyceridemia is elevated fasting triglycerides, typically reflecting insulin resistance, visceral adiposity, alcohol intake, or genetic dyslipidemia. Severe elevation raises pancreatitis risk.

Leptin Resistance

Hypothalamic Leptin Resistance

Leptin resistance is impaired hypothalamic response to leptin despite elevated circulating levels, perpetuating visceral adiposity, hyperphagia, and metabolic dysfunction.

sexual wellness

Sexual wellness conditions

Erectile Dysfunction

ED · Impotence

Erectile dysfunction is the persistent inability to achieve or maintain an erection sufficient for satisfactory sexual function. It is typically multifactorial — vascular, hormonal, neurogenic, and psychological — and frequently signals earlier cardiovascular or metabolic change.

Benign Prostatic Hyperplasia

BPH · Enlarged Prostate

Benign prostatic hyperplasia is non-malignant enlargement of the prostate causing lower urinary tract symptoms (LUTS). DHT is a primary driver; PSA monitoring is standard.

Premature Ejaculation

PE · Early Ejaculation

Premature ejaculation is recurrent ejaculation within approximately one minute of penetration with associated distress. Pathophysiology includes serotonergic tone, sensitivity, and psychological factors.

longevity

Longevity conditions

Age-Related Hormone Decline

Hormonal Aging · Endocrine Senescence

Age-related hormone decline is the gradual, predictable downshift of testosterone, estradiol, growth hormone signaling, DHEA, and thyroid axis sensitivity that begins in midlife. It is a physiological pattern — not a single disease — and is the substrate underneath many adult quality-of-life changes.

Iron Deficiency Anemia

IDA · Microcytic Anemia

Iron deficiency anemia is the most common nutritional anemia worldwide. It presents with fatigue, dyspnea, hair shedding, and impaired exercise capacity.

Vitamin D Deficiency

Hypovitaminosis D

Vitamin D deficiency is widespread in adults living at higher latitudes and contributes to bone, immune, and metabolic health risk.

Vitamin B12 Deficiency

Cobalamin Deficiency

Vitamin B12 deficiency causes macrocytic anemia and, distinctively, neurologic damage that can be irreversible if not corrected promptly.

Magnesium Deficiency

Hypomagnesemia

Magnesium deficiency contributes to muscle cramps, sleep disruption, palpitations, and metabolic dysregulation. Serum magnesium is insensitive; RBC magnesium detects deficits earlier.

Chronic Low-Grade Inflammation

Inflammaging · Subclinical Inflammation

Chronic low-grade inflammation is sustained, low-intensity activation of inflammatory pathways without overt disease. It is increasingly implicated in cardiovascular, metabolic, and neurodegenerative disease risk.

Osteoporosis

Low Bone Density · Postmenopausal Bone Loss

Osteoporosis is loss of bone mineral density that increases fracture risk. It is diagnosed by DXA T-score ≤ −2.5 or by a fragility fracture.

Sarcopenia

Age-Related Muscle Loss

Sarcopenia is age-related loss of skeletal muscle mass, strength, and function. It is a major driver of frailty, disability, and mortality in older adults.

Adult Growth Hormone Deficiency

GHD · Somatopause

Adult growth hormone deficiency presents with reduced lean mass, increased visceral adiposity, fatigue, and reduced exercise capacity. Confirmation requires stimulation testing.

Obstructive Sleep Apnea

OSA · Sleep-Disordered Breathing

Obstructive sleep apnea is recurrent upper airway collapse during sleep producing fragmented sleep, hypoxemia, and substantial cardiometabolic risk.

Chronic Fatigue Syndrome (ME/CFS)

Myalgic Encephalomyelitis · Systemic Exertion Intolerance Disease

ME/CFS is a complex chronic illness characterized by post-exertional malaise, unrefreshing sleep, cognitive impairment, and disabling fatigue not relieved by rest.

Atherosclerotic Cardiovascular Disease

ASCVD · Coronary Artery Disease

Atherosclerotic cardiovascular disease is the leading cause of death globally. Risk is driven by lipoprotein burden, hypertension, glycemic dysregulation, inflammation, and lifestyle.

Hyperhomocysteinemia

Elevated Homocysteine

Hyperhomocysteinemia is an elevated plasma homocysteine, associated with cardiovascular and cognitive risk. Common drivers include B12, folate, and B6 insufficiency and MTHFR polymorphisms.

Elevated Lipoprotein(a)

High Lp(a) · Lp(a) Excess

Elevated lipoprotein(a) is a largely genetic, lifelong risk amplifier for atherosclerotic cardiovascular disease and aortic stenosis. It is measured once in adulthood to confirm baseline risk.

Mild Cognitive Impairment

MCI · Pre-Dementia Cognitive Decline

Mild cognitive impairment is measurable cognitive change beyond normal aging without functional impairment. Vascular, metabolic, and hormonal drivers are partially modifiable.

Depression

Major Depressive Disorder · MDD

Depression is a recurrent mood disorder with biological, hormonal, and psychosocial drivers. Thyroid dysfunction, low testosterone, vitamin D and B12 insufficiency, and inflammation can amplify symptoms.

Chronic Insomnia

Sleep-Onset Insomnia · Sleep-Maintenance Insomnia

Chronic insomnia is persistent difficulty initiating or maintaining sleep with daytime impairment. Cortisol dysregulation, perimenopausal estradiol decline, low progesterone, and thyroid abnormalities are common drivers.

Osteopenia

Low Bone Mass

Osteopenia is reduced bone mineral density above the osteoporosis threshold, signaling accelerated bone-loss trajectory. Estradiol, testosterone, vitamin D, and calcium status are modifiable drivers.

Frailty Syndrome

Age-Related Frailty

Frailty is a clinical state of decreased physiologic reserve marked by weakness, exhaustion, slow gait, and weight loss. It predicts adverse outcomes and overlaps with sarcopenia and hormonal decline.

Mitochondrial Dysfunction

Bioenergetic Dysfunction · Acquired Mitochondrial Insufficiency

Acquired mitochondrial dysfunction is reduced cellular energy production driven by oxidative stress, nutrient insufficiency, and metabolic disease. It manifests as fatigue, poor recovery, and exercise intolerance.