oMeds
Knowledge graph · Symptoms

Canonical Symptom Entities

Symptoms in optimization medicine are signals, not diagnoses. Each canonical symptom page maps the conditions, biomarkers, and pathways that resolve it.

Medically reviewed
Dr. Laura Purdy · MD, MBA
Clinical Director, oMeds
Last reviewed

Fatigue

Persistent Tiredness · Low Energy

Fatigue is persistent low energy not relieved by rest. In optimization medicine it is treated as a signal, not a diagnosis: a downstream marker of hormonal, metabolic, thyroid, nutrient, or sleep dysfunction.

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Low Libido

Hypoactive Sexual Desire · Reduced Sex Drive

Low libido is reduced sexual desire that causes personal distress. In adults it is most often a downstream signal of hormonal change, relationship/psychological context, medication side effects, or metabolic dysfunction.

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Brain Fog

Cognitive Fog · Mental Cloudiness

Brain fog describes the subjective experience of slowed processing, poor word recall, and impaired focus. It is a symptom — not a diagnosis — and is commonly hormonal, metabolic, inflammatory, or sleep-driven.

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Unexplained Weight Gain

Adiposity Increase · Body Composition Shift

Unexplained weight gain — particularly visceral and accelerated — is rarely a caloric story alone. It commonly maps to insulin resistance, perimenopausal estradiol shifts, low testosterone, thyroid dysfunction, or sleep loss.

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Poor Recovery

Delayed Recovery · Training Recovery Deficit

Poor recovery is the persistent inability to bounce back from training, work, or stress at expected timelines. It is a multi-system signal — hormonal, inflammatory, nutritional, sleep-related — and is one of the earliest indicators of axis dysregulation.

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Sleep Disturbance

Insomnia · Fragmented Sleep

Sleep disturbance — difficulty falling asleep, fragmented sleep, or early awakening — is both a symptom and an upstream driver of nearly every hormonal and metabolic dysregulation tracked on the panel.

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Hot Flashes

Vasomotor Symptoms · Night Sweats

Hot flashes are sudden, intense sensations of heat — often with flushing and sweating — driven by perimenopausal and postmenopausal narrowing of the thermoregulatory zone. They can persist for years and disrupt sleep, mood, and cognition.

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Mood Changes

Mood Lability · Irritability

New-onset mood lability, irritability, or low mood in midlife is frequently hormonally driven and not adequately addressed by mental-health treatment alone. Estradiol, progesterone, testosterone, thyroid, and inflammation are common substrates.

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Reduced Muscle Mass

Sarcopenia · Lean Mass Loss

Progressive lean-mass loss accelerates in midlife and is one of the strongest predictors of long-term metabolic and functional decline. It is hormonally and nutritionally driven and is reversible with resistance training plus targeted biomarker optimization.

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