Fatigue
Also known as: Persistent Tiredness · Low Energy · Exhaustion
Fatigue is persistent low energy not relieved by rest. In optimization medicine it is treated as a signal, not a diagnosis: a downstream marker of hormonal, metabolic, thyroid, nutrient, or sleep dysfunction.
What you need to know
Persistent fatigue is one of the most common reasons adults seek optimization care, and it is almost always multifactorial. A full workup reviews testosterone (men), estradiol/progesterone (women), thyroid (TSH, free T3, free T4, reverse T3), iron (ferritin), B12, vitamin D, A1C, fasting insulin, and inflammation (hs-CRP). Sleep architecture, training load, alcohol, and stress are reviewed in parallel. Fatigue rarely resolves with a single intervention — the durable answer comes from biomarker-guided sequencing.
How this entity relates
Every entity in the oMeds knowledge graph cross-links to the conditions, biomarkers, medications, and educational surfaces it touches.
Underlying conditions
- Low Testosterone
- Perimenopause
- Menopause
- Metabolic Syndrome
- Insulin Resistance
- Obesity
- Erectile Dysfunction
- Age-Related Hormone Decline
- Hypothyroidism
- Hashimoto's Thyroiditis
- Type 2 Diabetes
- Prediabetes
- Hypertension
- Non-Alcoholic Fatty Liver Disease (NAFLD)
- Cortisol Dysregulation
- Iron Deficiency Anemia
- Vitamin D Deficiency
- Vitamin B12 Deficiency
- Chronic Low-Grade Inflammation
- Sarcopenia
- Adult Growth Hormone Deficiency
- Obstructive Sleep Apnea
- Chronic Fatigue Syndrome (ME/CFS)
- DHEA Deficiency
- Atherosclerotic Cardiovascular Disease
- Adrenal Insufficiency
- Cushing Syndrome
- Subclinical Hypothyroidism
- Endometriosis
- Uterine Fibroids
- Metabolic Dysfunction-Associated Steatohepatitis
- Hyperhomocysteinemia
- Hypertriglyceridemia
- Mild Cognitive Impairment
- Depression
- Chronic Insomnia
- Frailty Syndrome
- Leptin Resistance
- Mitochondrial Dysfunction
- Premenstrual Dysphoric Disorder
Bring this entity into your optimization pathway
Every condition, symptom, biomarker, and medication on oMeds is reviewed by a licensed provider and recalibrated against the standardized biomarker panel.