Insulin Resistance
Also known as: Impaired Insulin Sensitivity · Pre-Diabetic Insulin Resistance
Insulin resistance is a state in which cells respond poorly to insulin, forcing the pancreas to secrete more insulin to maintain euglycemia. It precedes prediabetes and metabolic syndrome by years and is reversible with targeted intervention.
What you need to know
Insulin resistance is the earliest detectable signal in the cardiometabolic decline pathway. Fasting glucose can remain in range for years while fasting insulin quietly rises — which is why insulin-only screening misses it. The HOMA-IR calculation, fasting insulin, A1C, triglyceride-to-HDL ratio, and ApoB together give a high-resolution picture. Reversal pathways include resistance training, sleep optimization, dietary pattern change, and — where indicated — GLP-1 receptor agonist optimization with provider oversight.
How this entity relates
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