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Medication · Cellular Cofactor / Coenzyme

NAD+ (Nicotinamide Adenine Dinucleotide)

Also known as: NAD · NAD Therapy · IV NAD+

NAD+ is a cellular coenzyme central to mitochondrial energy production, DNA repair, and longevity signaling. Provider-reviewed NAD+ optimization is delivered via IV or precursor-based pathways and is positioned in the longevity, recovery, and cognitive support arc.

Medically reviewed
Dr. Laura Purdy · MD, MBA
Clinical Director, oMeds
Last reviewed
Mechanism of action

Serves as a required cofactor for sirtuin and PARP enzymes involved in DNA repair, mitochondrial function, and cellular energy metabolism. Levels decline with age.

Overview

What you need to know

NAD+ levels fall measurably with age and under chronic metabolic or inflammatory stress. Restoring NAD+ supports mitochondrial output, sirtuin-mediated longevity pathways, and PARP-driven DNA repair. Optimization pathways include IV NAD+ and precursor strategies (NMN, NR). Provider-reviewed candidacy review weighs cardiovascular context, current medications, and biomarker baseline. NAD+ is positioned as longevity infrastructure rather than a symptomatic intervention.

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