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Answer · biomarkers

What is non-HDL cholesterol?

Short answer

Non-HDL cholesterol equals total cholesterol minus HDL cholesterol, capturing all atherogenic lipoprotein cholesterol in one number.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

Non-HDL cholesterol is calculated, requires no additional assay, and is a strong predictor of cardiovascular risk. It captures LDL, VLDL, and remnant cholesterol — the full atherogenic cholesterol load. Major guidelines (AHA/ACC, ESC) endorse non-HDL as a secondary target, especially when triglycerides exceed 200 mg/dL, where calculated LDL-C becomes unreliable. Within oMeds review, non-HDL is read on every standard lipid panel and is interpreted alongside ApoB and metabolic context.

Educational. Not a substitute for individualized provider review.

References & sources
  • Non-HDL Cholesterol — Primary source · oMeds
  • Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29

Related answers

Non-HDL vs LDL?
LDL cholesterol measures one atherogenic fraction; non-HDL captures all atherogenic cholesterol (LDL plus VLDL plus remnants). Non-HDL is preferred when triglycerides are high.
Primary source
Non-HDL Cholesterol