oMeds
All answers
Answer · longevity

What is NAD+ therapy?

Short answer

NAD+ is a coenzyme essential to mitochondrial energy production. NAD+ levels decline with age. Injectable and IV NAD+ raises systemic levels; oral precursors (NR, NMN) work indirectly.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme required for mitochondrial energy production, DNA repair, and sirtuin activity. NAD+ levels decline with age, and the working hypothesis driving NAD+ therapy is that restoring NAD+ availability supports cellular function and mitigates aspects of cellular aging. Delivery options include injectable NAD+ (the most efficient at raising serum levels), IV infusions, and oral precursors (nicotinamide riboside, NMN), which raise NAD+ indirectly through salvage pathways. Clinical evidence is encouraging but still maturing. oMeds provider review individualizes route and dose, typically pairing NAD+ with broader longevity-pathway markers.

Educational. Not a substitute for individualized provider review.

References & sources
  • Longevity pathways — Primary source · oMeds
  • Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29
Primary source
Longevity pathways