How does semaglutide work?
Semaglutide is a GLP-1 receptor agonist that slows gastric emptying, increases satiety, and improves glycemic control. It produces 12-15% average weight loss over 12-18 months when paired with lifestyle support.
Full answer
Semaglutide is a long-acting GLP-1 (glucagon-like peptide-1) receptor agonist. It works through three principal mechanisms: slowing gastric emptying, increasing satiety via central GLP-1 receptors, and improving glycemic control through glucose-dependent insulin secretion and reduced glucagon. Average weight loss in clinical trials is 12-15% over 12-18 months when paired with lifestyle support — meaningfully greater than older weight-loss pharmacotherapy. oMeds provider review requires baseline metabolic panel, kidney function (eGFR), thyroid status, and (when indicated) pancreas history. Recalibration cadence monitors response and tolerability.
Educational. Not a substitute for individualized provider review.
- Metabolic optimization — Primary source · oMeds
- Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29