oMeds
All answers
Answer · longevity

What is ipamorelin?

Short answer

Ipamorelin is a selective growth hormone secretagogue that stimulates pituitary GH release without meaningfully raising cortisol or prolactin.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

Ipamorelin acts on the ghrelin/GHS receptor to trigger pulsatile GH release with notable selectivity — it does not raise cortisol or prolactin to a meaningful degree, unlike older GH secretagogues. Within oMeds review, ipamorelin is provider-prescribed alongside sermorelin or other GHRH analogs in performance and recovery pathways, monitored against IGF-1 trend, and discontinued if biomarkers or symptoms do not respond.

Educational. Not a substitute for individualized provider review.

References & sources
  • Peptide Therapy pathway — Primary source · oMeds
  • Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29

Related pathways

All pathways →

Related answers

Sermorelin vs ipamorelin?
Sermorelin is a GHRH analog acting upstream of the pituitary; ipamorelin is a selective GH secretagogue. They are commonly combined to amplify pulsatile GH release.
Primary source
Peptide Therapy pathway