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Answer · longevity
Sermorelin vs ipamorelin — which is right for me?
Short answer
Sermorelin is a GHRH analog acting upstream of the pituitary; ipamorelin is a selective GH secretagogue. They are commonly combined to amplify pulsatile GH release.
Reviewed by Dr. Laura PurdyMay 29, 2026
Full answer
Sermorelin and ipamorelin both raise endogenous growth hormone but through distinct receptors. Sermorelin is a GHRH analog that triggers pituitary GH release; ipamorelin is a selective ghrelin/GHS receptor agonist with minimal effect on cortisol and prolactin. Combination therapy amplifies pulsatile GH release. Within oMeds review, selection depends on baseline IGF-1, goals, and provider judgment; response is monitored against IGF-1 trend rather than acute GH measurements.
Educational. Not a substitute for individualized provider review.
References & sources
- Peptide Therapy pathway — Primary source · oMeds
- Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29
Related pathways
All pathways →Primary source
Peptide Therapy pathway