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Answer · metabolic

What is adiponectin?

Short answer

Adiponectin is a fat-cell hormone that enhances insulin sensitivity and exerts anti-inflammatory effects. Higher levels track with better metabolic health.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

Adiponectin is secreted by adipocytes and supports insulin sensitivity, lipid handling, and vascular health. Low adiponectin is associated with insulin resistance, type 2 diabetes, and cardiovascular disease, while higher levels are favorable. Levels can rise modestly with weight loss, aerobic exercise, and Mediterranean-style nutrition. Within oMeds review, adiponectin is read in advanced metabolic workups alongside fasting insulin, HOMA-IR, leptin, and lipids; trend matters more than absolute values.

Educational. Not a substitute for individualized provider review.

References & sources
  • Adiponectin — Primary source · oMeds
  • Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29

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Insulin resistance develops when cells respond less to insulin, forcing the pancreas to produce more to keep glucose normal. It precedes type 2 diabetes by years to decades.
Primary source
Adiponectin