Tadalafil
Also known as: Cialis · Adcirca · Long-Acting PDE5 Inhibitor
Tadalafil is a long-acting PDE5 inhibitor used for erectile dysfunction and benign prostatic hyperplasia symptoms. Its long half-life (~17.5 h) supports daily-dose strategies in addition to on-demand use.
Inhibits phosphodiesterase type 5, increasing cyclic GMP in vascular smooth muscle and producing sustained vasodilation in the corpus cavernosum and pulmonary vasculature.
What you need to know
Tadalafil's half-life of roughly 17.5 hours distinguishes it from sildenafil. Daily low-dose tadalafil is often selected when spontaneity matters or when BPH symptoms coexist. Provider-reviewed evaluation reviews cardiovascular context (nitrate use is an absolute contraindication), blood pressure, hepatic function, and concurrent medications. ED is frequently a downstream signal of vascular or metabolic change, so a complete evaluation includes lipids, ApoB, A1C, and hormonal context.
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