oMeds
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Comparison · metabolic

Wegovy vs Zepbound

Wegovy and Zepbound are the two FDA-approved weight-management brands of the GLP-1 class. Wegovy is semaglutide; Zepbound is tirzepatide. The molecule-level comparison is the same comparison as semaglutide vs tirzepatide — Wegovy is GLP-1 mono-agonism, Zepbound is dual GIP/GLP-1. Choice is provider-reviewed against biomarkers, tolerance, cardiovascular history, and access.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Wegovy (semaglutide)
Zepbound (tirzepatide)
FDA indication
Chronic weight management
Both approved for weight management in qualifying adults.
Chronic weight management
Molecule
Semaglutide
Tirzepatide
Mechanism
GLP-1 receptor agonist
Dual GIP / GLP-1 receptor agonist
Avg. weight loss (max dose)
~15% of body weight
~20–22% of body weight
Dosing cadence
Weekly subcutaneous
Weekly subcutaneous
Cardiovascular outcome data
Established in defined populations
Outcome trials maturing
Lean-mass defense plan
Required protocol
Required protocol
Choose Wegovy (semaglutide)

Choose Wegovy when the longer cardiovascular outcome track record matters, when access favors semaglutide, or when prior tolerance favors GLP-1 mono-agonism.

Choose Zepbound (tirzepatide)

Choose Zepbound when the priority is the larger average weight-loss effect at maximum tolerated dose and candidacy and access support it.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Are Wegovy and Ozempic the same?

Same molecule (semaglutide), different FDA-approved indication. Wegovy is approved for chronic weight management; Ozempic is approved for type-2 diabetes. Dosing schedules differ.

Are Zepbound and Mounjaro the same?

Same molecule (tirzepatide), different FDA-approved indication. Zepbound is approved for chronic weight management; Mounjaro is approved for type-2 diabetes.

Next step

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