oMeds
All comparisons
Comparison · sexual wellness

Sildenafil vs Vardenafil

Sildenafil and vardenafil are short-acting PDE5 inhibitors used for erectile dysfunction. Both have a ~4–6 hour window of effect; vardenafil has slightly higher PDE5 selectivity but the clinical difference is modest. Tadalafil is the modern default for most candidates due to a longer window.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Sildenafil
Vardenafil
Onset
30–60 minutes
25–60 minutes
Duration
~4–6 hours
~4–6 hours
Food effect
Reduced absorption with high-fat meals
Reduced absorption with high-fat meals
PDE5 selectivity
Standard
Slightly higher
Modern positioning
Common on-demand option
Less prescribed than sildenafil or tadalafil
Pathway
Sexual wellness
Not offered by oMeds
Choose Sildenafil

Sildenafil is appropriate for on-demand use when a short-window PDE5 inhibitor is preferred.

Choose Vardenafil

Vardenafil is appropriate in select cases of sildenafil intolerance and is not currently in the oMeds formulary.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Is one more effective?

At appropriate doses, response rates are comparable for the same candidate.

Is tadalafil usually better?

For many candidates, tadalafil's longer window and daily-dose option are preferred — that is the provider-reviewed default.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

Begin assessment