oMeds
All comparisons
Comparison · longevity

Sermorelin vs Ipamorelin

Sermorelin and ipamorelin are growth hormone secretagogues that stimulate endogenous GH release. Sermorelin is a GHRH analog with a recognized clinical history. Ipamorelin is a GH-releasing peptide with a cleaner side-effect signal and is often combined with CJC-1295 in compounded peptide therapy.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Sermorelin
Ipamorelin
Class
GHRH analog
GHRP (ghrelin mimetic)
GH pulse pattern
Mimics natural pulsatile GH
Discrete GH pulse
Cortisol/prolactin signal
Minimal
Minimal
Common pairing
Standalone
Often combined with CJC-1295
Half-life
~10 minutes
~2 hours
Pathway
Peptide therapy
Not currently in oMeds formulary
Choose Sermorelin

Sermorelin is appropriate when a GHRH-analog approach is provider-reviewed and a single-agent peptide pathway is preferred.

Explore pathway
Choose Ipamorelin

Ipamorelin is appropriate in select compounded peptide protocols and is not currently in the oMeds formulary.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Are these the same as HGH?

No — they stimulate endogenous GH release rather than supplying exogenous HGH.

How is candidacy determined?

Through a synchronous provider-reviewed assessment with IGF-1 and full biomarker context.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

Begin assessment