Metformin vs Berberine
Both activate AMPK and improve glucose control. Metformin has decades of evidence and is prescription. Berberine is over-the-counter with shorter half-life and similar magnitude in head-to-head trials on glycemic markers, but weaker long-term outcome data.
Metformin is the provider-reviewed first-line for glycemic and longevity support when prescription is appropriate.
Berberine is appropriate as an OTC option when prescription is declined or unavailable.
Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.
Frequently asked
Can both be combined?
Generally not — overlapping mechanism without additive benefit.
Which has more evidence?
Metformin by a wide margin for long-term outcomes.
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The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.
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