oMeds
All comparisons
Comparison · longevity

Low-Dose vs Standard Naltrexone

LDN (1.5–4.5 mg) is used for autoimmune modulation, chronic pain, and inflammation via transient opioid-receptor blockade and endorphin rebound. Standard 50 mg dosing is for opioid and alcohol use disorder. Indications are entirely distinct.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Low-dose naltrexone (LDN)
Standard naltrexone (50 mg)
Dose
1.5–4.5 mg nightly
50 mg daily
Mechanism
Transient blockade, endorphin rebound
Continuous opioid receptor blockade
Primary indications
Autoimmune, inflammation, pain
Opioid / alcohol use disorder
Side effects
Vivid dreams (transient)
Nausea, fatigue
Formulation
Compounded
FDA-approved tablet
Choose Low-dose naltrexone (LDN)

LDN is appropriate for autoimmune, inflammation, and chronic-pain indications under provider review.

Choose Standard naltrexone (50 mg)

Standard naltrexone is appropriate for opioid or alcohol use disorder.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Why is LDN compounded?

Standard tablets are not available at sub-5 mg doses.

Is LDN evidence-based?

Yes for select autoimmune contexts; emerging for others.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

Begin assessment