oMeds
All comparisons
Comparison · hormone optimization

Levothyroxine vs Desiccated Thyroid

Levothyroxine is precisely standardized synthetic T4 and the modern default. Desiccated thyroid is porcine-derived T4 + T3 at a fixed ratio favoring T3. A subset of candidates prefer NDT for symptom control, accepting batch variability.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Levothyroxine (synthetic T4)
Desiccated thyroid (NDT)
Composition
Synthetic T4 only
Porcine T4 + T3 (fixed ratio)
Standardization
Precise
Batch-variable
Modern positioning
Default
Selective
T3:T4 ratio
0 : 1
~1 : 4 (higher T3 than human)
Dosing flexibility
Titratable in micrograms
Coarser grain-based dosing
Choose Levothyroxine (synthetic T4)

Levothyroxine is the provider-reviewed default for hypothyroidism.

Choose Desiccated thyroid (NDT)

Desiccated thyroid is selective — appropriate where candidate response and biomarkers support it.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Is NDT 'more natural'?

Porcine-derived, but the ratio is non-human and may overshoot T3 in some candidates.

Can I switch back?

Yes — provider review handles conversion.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

Begin assessment