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Comparison · peptides

CJC-1295 + Ipamorelin vs Sermorelin

CJC-1295 (GHRH analog) plus ipamorelin (selective GHRP) produces synergistic GH pulse with minimal cortisol or prolactin impact. Sermorelin is a simpler single-peptide GHRH analog. The stack is the modern default for sustained GH protocols.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
CJC-1295 + Ipamorelin
Sermorelin
Mechanism
GHRH + selective GHRP synergy
GHRH only
GH pulse magnitude
Larger
Modest
Cortisol/prolactin impact
Minimal (ipamorelin selectivity)
Minimal
Cost
Higher
Lower
Cadence
Nightly
Nightly
Choose CJC-1295 + Ipamorelin

The stack is appropriate when sustained GH support is the goal and the candidate accepts higher complexity and cost.

Choose Sermorelin

Sermorelin alone is appropriate for first cycles and budget-conscious GHRH support.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Why ipamorelin over other GHRPs?

Ipamorelin is selective and avoids the cortisol/prolactin spikes of older GHRPs.

Is the stack safer than older GH protocols?

It preserves pulsatility, unlike exogenous HGH.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

Begin assessment