oMeds
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Comparison · metabolic

Fasting Insulin vs HOMA-IR

Fasting insulin is a direct measure. HOMA-IR combines fasting insulin and fasting glucose into a single insulin-resistance index. HOMA-IR is more sensitive for early insulin resistance than either marker alone.

Reviewed by Dr. Laura PurdyMay 29, 2026
Attribute
Fasting insulin
HOMA-IR
What it measures
Insulin level
Insulin resistance index
Inputs
Insulin only
Insulin × glucose / 405
Sensitivity for early IR
Moderate
Higher
Standardization
Assay-dependent
Calculated, less assay drift
Decisional weight
Anchor marker
Resolves borderline cases
Choose Fasting insulin

Fasting insulin is the anchor marker on the metabolic panel and is tracked across recalibration cadence.

Choose HOMA-IR

HOMA-IR is decisive when fasting insulin and glucose are borderline or when early insulin resistance is suspected.

Educational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.

Frequently asked

Do I need both?

HOMA-IR requires fasting insulin and fasting glucose — both are drawn together.

Which is the modern standard?

HOMA-IR is the preferred decisional index; fasting insulin remains the underlying anchor.

Next step

Take the optimization assessment.

The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.

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