Estradiol Gel vs Patch
Transdermal estradiol — gel or patch — is the modern default in BHRT because it bypasses first-pass hepatic metabolism. Gel offers dose flexibility per pump; patch offers continuous delivery with twice-weekly application.
Gel is appropriate when daily dosing flexibility and fine titration are preferred.
Explore pathwayPatch is appropriate when steady-state delivery and minimal daily handling are preferred.
Explore pathwayEducational. Final pathway selection is provider-reviewed via synchronous video consultation against your biomarkers, history, and goals.
Frequently asked
Is one more effective?
At equivalent estradiol exposure, symptom relief and biomarker response are comparable.
Can a candidate switch between them?
Yes — provider-reviewed at recalibration with a follow-up estradiol read.
Take the optimization assessment.
The adaptive assessment maps your symptoms, history, and goals to candidate pathways — and routes you into provider review.
Begin assessment