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Answer · metabolic

What is semaglutide?

Short answer

Semaglutide is a GLP-1 receptor agonist used for type 2 diabetes and weight management. It improves glycemic control and produces meaningful, sustained weight loss.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

Semaglutide is a long-acting GLP-1 receptor agonist that lowers glucose, reduces appetite, slows gastric emptying, and supports durable weight reduction. Outcome data demonstrate substantial cardiovascular risk reduction in established cardiovascular disease and sustained weight loss in obesity. Within oMeds review, semaglutide is prescribed by licensed providers after a comprehensive biomarker review (A1C, fasting insulin, lipids, CMP, thyroid status) and is paired with nutritional and behavioral support. Discontinuation typically reverses weight loss without ongoing lifestyle change.

Educational. Not a substitute for individualized provider review.

References & sources
  • Metabolic Optimization pathway — Primary source · oMeds
  • Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29

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Related answers

Semaglutide vs tirzepatide?
Tirzepatide produces greater weight loss and A1C reduction than semaglutide in head-to-head trials. Choice depends on goals, tolerability, prior response, and provider review.
What is tirzepatide?
Tirzepatide is a dual GIP and GLP-1 receptor agonist with greater weight reduction and glycemic improvement than GLP-1 monotherapy in head-to-head trials.
Primary source
Metabolic Optimization pathway