What is male hypogonadism?
Hypogonadism is clinically meaningful symptoms plus persistently low morning testosterone. Diagnosis requires two morning total testosterone draws plus free testosterone and SHBG context.
Full answer
Male hypogonadism is the clinical syndrome of low testosterone production with associated symptoms — low libido, erectile dysfunction, fatigue, depressed mood, loss of muscle mass, and reduced bone density. Diagnosis follows Endocrine Society guidance: persistently low morning total testosterone on two separate draws, combined with consistent symptoms, with free testosterone and SHBG providing biological-availability context. Hypogonadism is classified as primary (testicular, with elevated LH/FSH) or secondary (pituitary/hypothalamic, with low or inappropriately normal LH/FSH). Workup informs candidacy for testosterone replacement vs LH-axis modulation (enclomiphene) vs underlying-cause treatment.
Educational. Not a substitute for individualized provider review.
- Total Testosterone — Primary source · oMeds
- Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29