oMeds
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Answer · hormone optimization

What is andropause (male hypogonadism)?

Short answer

Andropause refers to age-related decline in testosterone production. When symptomatic and biochemically confirmed, it is diagnosed as male hypogonadism.

Reviewed by Dr. Laura PurdyMay 29, 2026

Full answer

Unlike menopause, testosterone decline in men is gradual rather than abrupt. Symptoms — fatigue, reduced libido, mood change, loss of lean mass, reduced exercise tolerance — overlap with many other conditions. Diagnosis requires two morning total testosterone measurements below the reference range with consistent symptoms, supplemented by free testosterone, SHBG, LH, FSH, prolactin, and thyroid status. Within oMeds review, hypogonadism is interpreted in full clinical context; secondary causes (medications, sleep apnea, opioid use) are addressed before defaulting to replacement.

Educational. Not a substitute for individualized provider review.

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