What is ANA (antinuclear antibodies)?

Full answer

Antinuclear antibodies (ANA) screen for autoimmune connective tissue disease including lupus, Sjögren's syndrome, scleroderma, and mixed connective tissue disease. Low-titer positives are common in healthy adults; titer, immunofluorescence pattern, and reflex testing drive interpretation. Within oMeds review, ANA is ordered selectively when symptoms suggest autoimmunity and is interpreted alongside RF, anti-CCP, complement levels, and clinical findings, never as a standalone diagnosis.

Educational. Not a substitute for individualized provider review.