What are the benefits of NAD+?
NAD+ is a cellular cofactor central to mitochondrial energy production, DNA repair, and sirtuin signaling. Restoring NAD+ levels is associated with improvements in cellular energy, recovery, cognitive clarity, and longevity-axis markers in candidates with documented decline.
Full answer
Nicotinamide adenine dinucleotide (NAD+) is a coenzyme present in every living cell. It powers the electron transport chain, fuels sirtuin-mediated longevity signaling, and is consumed by PARP enzymes during DNA repair. NAD+ levels decline with age, chronic inflammation, and metabolic stress, and that decline correlates with reduced mitochondrial efficiency. NAD+ optimization is built on restoring the substrate the cell needs to run its core machinery — not on a single endpoint. Reported clinical signals include cellular energy, cognitive clarity, recovery from physical stress, and improvements in longevity-axis markers in candidates with documented decline. NAD+ is delivered by injection, IV, or oral precursor depending on candidacy, lifestyle, and continuity preferences — provider-reviewed in every case. It is not a stimulant and is not appropriate for every patient.
Educational. Not a substitute for individualized provider review.
- NAD+ pathway — Primary source · oMeds
- Metabolic intelligence — Reference · oMeds Learn
- Reviewed by Dr. Laura Purdy, MD, MBA · Clinical Director, oMeds · Last reviewed 2026-05-29