oMeds
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Answer · hormone optimization

Which pathway addresses persistent low energy?

Short answer

Low energy is screened identically to chronic fatigue: sleep, thyroid, iron, B12, vitamin D, glucose, and mood. Repletion is first-line. Hormone optimization is layered when biomarkers and symptoms align.

Reviewed by Dr. Laura PurdyJune 3, 2026

Full answer

Low energy and fatigue share an identical first-pass workup: sleep, thyroid, ferritin, B12, vitamin D, glucose, hs-CRP, and mood. Reversible drivers are addressed first because hormone optimization cannot compensate for unaddressed deficiency. Men with confirmed low testosterone are evaluated for TRT. Peri/menopausal women are evaluated for BHRT. NAD+ may be considered when cellular and longevity-axis goals are present. Every initiation is synchronous-video reviewed against the patient's biomarker baseline.

Educational. Not a substitute for individualized provider review.

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